NAME: Steven S. Guest, M.D.

HOME ADDRESS: 1281 Kimmer Ct Lake Forest, IL 60045

Email: steven_guest@baxter.com guestnest5@yahoo.com

DATE OF BIRTH: December 27, 1956

PLACE OF BIRTH: Nashville, Tennessee

MARITAL STATUS: Married

CURRENT POSITION:

Medical Affairs
Baxter Healthcare
Renal Division
1620 Waukegan Road
McGaw Park, Illinois 60085

POSITION 2004-2008:

Staff Nephrologist
Medical Director- Peritoneal Dialysis Unit
Kaiser Permanente- Santa Clara
710 Lawrence Expressway
Santa Clara, CA. 95051

Adjunct Clinical Associate Professor of Medicine,
Stanford University School of Medicine
Stanford, CA

Chairman- PD Workgroup
Northern California Kaiser Permanente

This committee monitors PD activities at 17 N.California Kaiser facilities and reports to the upper administration on status of PD in NCAL KP.

PREVIOUS POSITION 1993-2004:

Medical Director-Peritoneal Dialysis Unit
Santa Clara Valley Medical Center
San Jose, California 95128

This was the PD Unit associated with the Stanford Division of
Nephrology where 5 renal fellows a year trained in PD, received
didactic education in PD care

EDUCATION:

1975-79 B.A. Chemistry, Emory College
Emory University, Atlanta, Georgia

1980-84 Medical Degree, Vanderbilt University
Nashville, Tennessee

POSTGRADUATE TRAINING:

1984-85 Intern in Medicine
George Washington University Hospital
Washington, D.C.

1985-87 Resident in Medicine
George Washington University Hospital
Washington, D.C.

1987-88 Chief Medical Resident
Mt. Auburn Hospital - Harvard Medical School
Cambridge, MA

1989-91 Nephrology Clinical and Research Fellow
Massachusetts General Hospital, Harvard Medical
School, Boston, MA 02114

1991-93 Research Fellow
Immunobiology Department
Massachusetts General Hospital-East
Boston, MA 02129

BOARD CERTIFICATION: Internal Medicine, January 15, 1988
Specialty Board in Nephrology, January 26, 1995

AWARDS AND HONORS:

High School Class President - Four Years

College Interfraternity Council President
and Rush Chairman

President ODK

Resident Advisor - Three Years

Thomas J. Watson Fellow
One Year Independent Study, International Center for Diarrheal Disease Research, B. Dacca, Bangladesh

Medical School Justin Potter Scholar
Four Year Scholarship

William Pearson Nutrition Scholarship,
Three Month Study, Cork, Ireland

Residency Selected by Senior Medical Students
to Receive the Sandoz Award for
Excellence in Teaching, Awarded to One
Senior Medical Resident

Attending
Bay Area Consumers’ Checkbook and San Jose Magazines Top Doctor List 2005 and 2007

Henry J. Kaiser Award for Clinical Teaching
Stanford Medical School- June 2007

Kaiser Permanente Housestaff Award

Sub-Specialist of the Year- June 2005, 2006, 2007, 2008

Authur L. Bloomfield Award in Recognition of
Excellence in the Teaching of Clinical Medicine
Stanford School of Medicine June 12, 2004

Henry J. Kaiser Award for Excellence in Teaching
Stanford School of Medicine Second Yr Class- 2003

Santa Clara Valley Medical Center, Department of Medicine
Attending of the Year -2003

2002 Nephrology Divisional Teaching Award, Stanford
University School of Medicine

Henry J. Kaiser Award for Excellence in Teaching
Stanford School of Medicine Second Yr Class- 1998

COMMITTEES: Co-Director, Stanford Medical School Renal Physiology Course -
Second Year Class. 2002-2006

Santa Clara Valley Medical Center:
Program Director, Transitional Internship 1994-2001

Lifeguard, Regional Managed Care Committee
1999 - 2001

Graduate Medical Education Committee
Acting Chairman
1999 - 2001

Institutional Coordinating Committee, Chairman
1994 - 2001

Graduate Medical Education Committee
1994 - 2001

Clinical Competence Committee
1994 - 2006

Medical Staff Board of Directors
1995 - 2001

Co-Chairman, 29th Annual Medical Symposium on Renal Disease, National Kidney Foundation of Northern California. Foster City, CA, September 1996

MAB Executive Committee, National Kidney Foundation of Northern California. 1996 - 1998

Chairman, 30th Annual Medical Symposium on Renal Disease, National Kidney Foundation of Northern California. Foster City, CA, September 1997

Human Subjects Review Committee ( Institutional Review Committee)
Santa Clara Valley Medical Center
1998 – 2001

MEMBERSHIP: American Society of Nephrology International Society of Peritoneal Dialysis

PUBLICATIONS:

The Financial Implications for Medicare of Greater Use of Peritoneal Dialysis. Neil N, Guest s, Wong L, et al. Clin Therapeutics 2009;31:880-888.

Tamoxifen Therapy for Encapsulating Peritoneal Sclerosis: Mechanism of Action and Update on Clinical Experiences. Accepted for publication. Perit Dial Int 2009;29:252-255.

Hypothesis: Gender and Encapsulating Peritoneal Sclerosis. Accepted for publication. Perit Dial Int 2009.

Celebration of the 50th Anniversary of the Thesis on Peritoneal Dialysis by Dr. Fred S.T. Boen. Guest S, Divino J, Krediet R. Perit Dial Int. Accepted for publication. Perit Dial Int.

Propofol infusion syndrome with rhabdomyolysis and acute renal failure. Submitted for publication- Critical Care Medicine. 2009.

Parachute PD: Percutaneous PD Catheter Placement for Acute and Chronic Initiation of PD. Submitted for publication NDT 2009.

Minimally Invasive Techniques for Placement of Peritoneal Dialysis Catheters. Manuscript in preparation. 2009.

Berthorst, R, Guest SS. An unusual cause of recurrent peritonitis. Submitted for publication. 2009 Peritoneal Dialysis International.

Circulating Growth Hormone Binding Protein Levels and Mononuclear Cell Growth Hormone Receptor Expresssion in Uremia . Greenstein J, Guest S, Tan J, et al.
J Renal Nutrition 2006; 16: 141-149.

Seto AH, Guest SS. Ertepenem-associated seizures in a peritoneal dialysis patient.
Ann Pharmacother 2005; 39: 352-56.

Lentine K, Guest SS. Diabetic muscle infarction in end-stage renal disease. Nephrol Dial Transpant 2004; 19: 664-669.

Guest S, Levitt L. Pure Red Blood Cell Aplasia Secondary to Antierythropoietin Antibodies in a North American Patient with End Stage Renal Disease. N Engl J Med, December 25, 2003.

Oakes DD, Adams GA, Sherck JP, Guest SS. A new operation with inadequate Brescia fistulae for preservation of more proximal veins. J Vasc Surg 2002; 36: 346-50.

Guest S. Vasopeptidase Inhibitors: A new class of antihypertensive medication. Nephrology Rounds 4(10):2001. Snell Medical Communication, Inc.

Guest S. Sodium intake and hypertension. Nephrology Rounds 4:2001. Snell Medical Communication, Inc.

Guest S. Uric Acid and the Kidney. Nephrology Rounds 3:2001. Snell Medical Communication, Inc.

Guest S. Hypertension in Hemodialysis Patients: Non-pharmacological Treatment Strategies. Nephrology Rounds 3:2000. Snell Medical Communication, Inc.

Guest S. Adverse Consequences of Chronic Metabolic Acidosis. Nephrology Rounds 2:1998. Snell Medical Communication, Inc.

Guest S, Erickson L. Combination Therapy Involving Ciprofloxacin for Peritonitis. Peritoneal Dial Int 16:316-320, 1996.

Guest S, Kirsch C, Baxter R, Sorooshian M, Young J. Infection of a Subclavian Venous Stent in a Hemodialysis Patient. Am J Kid Dis 26:377-380, 1995.

Rubin NT, Haller CI, Guest SS, Curhan GC, Rabb HA, Russell PS, Cosimi AB, Delmonico FL, Auchincloss H, Hyman GA. Reduced Recurrence of Focal Segmental Glomerulosclerosis in Adult Renal Allografts During the Cyclosporine Era: The MGH Population. J Am Soc Nephrol 1:769, 1990.

Nicassio PM, Solomon GS, Guest SS, McCullough JE. Emigration Stress and Language Proficiency as Correlates of Depression in a Sample of Southeast Asian Refugees. Int J Soc Psych 32:22-28, 1986.

Pennisi A, Parenti M, Stevens A, Guest S, Simon G, Wilson W. Paranasal Sinus Mucormycosis in an Immunologically Competent Host. Am J Otolaryngol 6:471, 1985.

Guest S, Sivit C, Meisler W, Stevens A, Simon G. Intracranial Tuberculosis Due to Mycobacterium Bovis. Comput Rad Spring 1986.

Forthal D, Guest S. Isospora Belli Enteritis in Three Homosexual Men. Am J Trop Med Hyg 33:1060-1064, 1984.

BOOKS

Peritoneal Dialysis Handbook( In press ).

BOOK CHAPTERS

Oakes D, Lebowitz E, Guest S: Inadequate arterial inflow as a cause of high recirculation in autologous arteriovenous fistulae: review of eleven cases, potential mechanisms, and recommendations for management. Accepted for publication.

Oakes D, Adams G, Sherck J, Guest S: Two to three year follow-up of forearm grafts used to salvage inadequate Brescia fistulae: Analysis of factors associated with long-term patency. In Henry ML, ed. Vascular Access for Hemodialysis VIII. Chicago, Ill: Access Medical Press: 2002.

Oakes D, Singh T, Guest S: Late onset of hand ischemia in a patient with a Brescia fistulae; an unusual cause for an unusual problem. In Henry ML, ed. Vascular Access for Hemodialysis VIII. Chicago, Ill: Access Medical Press, 2002.

Jani A, Guest S, Lafayette RA. Arthropathies and bone diseases in hemodialysis and peritoneal dialysis patients. in Lameire N, Mehta R, ed. Complications of Dialysis. New York, NY: Marcel Dekker Inc; 2000:343-359.

Rabkin R, Guest S, Schaefer F. The Kidney and the Insulin-like Growth Factor-1 in Health and Disease. In Nutrition and the Insulin-like Growth Factor System. Ed. S Houston, J Holly and E Feldman. Humana Press. Page 227-248, 2004.

Guest S. Acute renal failure. In Surgery Clerkship Manual. Adams GA, ed. Mosby. St. Louis, MO, USA, 2003..

Guest S. Acid-base abnormalities. In Surgery Clerkship Manual. Adams GA, ed. Mosby. St. Louis, MO, USA, 2003.

ABSTRACTS, LETTERS, AND POSTER PRESENTATIONS (partial listing):


Invited speaker at the Peritoneal Dialysis University sponsored by Wake Forest University School of Medicine.

Invited speaker at the Peritoneal Dialysis Academy, University of Alabama School of Medicine

Speaker at Baxter Renal’s PD universities across the US.

Guest S, Law D, Hamilton L, Ordonez J. Variations in PD Utilization and Cost Implications in a Large US Health Maintenance Organization. Accepted ADC, Miami, 2008.

Guest S, Law D,Reddy C, Hamilton L, Ordonez J. Nephrologist Survey of Desired PD Utilization and Barriers to Growth of PD in a Large Health Maintenance Organization. Accepted ADC, Miami, 2008.

Rotaru D, Guest S. Permanent Neurologic Sequelae from Acute Intermittent Porphyria in a Hemodialysis Patient. Accepted ADC, Miami, 2008.

SS Guest: Treatment of Severe Congestive Heart Failulre with Icodextrin. N. American Peritoneal Dialysis Meeting-Hollywood Fla. June 2007.

N.Patel, S Guest: Medication Compatabilities with Icodextrin. N. American Peritoneal Dialysis Meeting- June 2007.

Encapsulating Peritoneal Sclerosis Due to Tuberculous Peritonitis. N. American Peritoneal Dialysis Meeting. June 2007.

Oakes DD, Singh T, Guest SS: Access revision based upon functional rather than anatomic abnormalities: a case of successful expectant management. Vascular Access for Hemodialysis IX Symposium. Orlando, FL. May 2004.

Guest S, Jobalia A, Fast S, Young J, Gilbert R: Dialysate sodium decay strategy for control of blood pressure and fluid gains in end stage renal disease. J Am Soc Nephrol 2002;13:213A.

Guest S, Lieu C, Jobalia A, Fast S, Gilbert R: Intracellular sodium variations in end stage renal disease. J Am Soc Nephrol 2002;13:590A.

Lentine K, Guest S: Clinicopathologic features of diabetic muscle infarction in end stage renal disease. J Am Soc Nephrol 2002;13: 590A.

Guest S, Wang C. Lactic Acidosis Associated with the Use of Metformin. J Am Soc Nephrol. Accepted for poster presentation, ASN 2001, San Francisco.

Rumyantzev-Goldfarb A, Fung A, Guest S. Correlations in Oncotic Pressure and Serum Osmolality During Hemodialysis Employing In-Line Blood Volume Monitoring. J Am Soc Nephrol. Accepted for poster presentation, ASN 2001, San Francisco.

Guest S, Jobalia A, Erickson L. Vancomycin-Sparing Peritonitis Protocol Involving Ofloxacin. J Am Soc Nephrol 10:302A, 1999

Guest S, Jobalia A, Erickson L: Vancomycin-Sparing Treatment Regimen Involving Ofloxacin for Peritoneal Dialysis Related Peritonitis. J Am Soc Nephrol 10:314A, 1999.

Santos J, Fast S, Guest S: Organic Acid Production During Bicarbonate-Based Hemodialysis. J Am Soc Nephrol 10:302A, 1999.

Santos J, Fast S, Guest S. High Bicarbonate Hemodialysis and Organic Anion Production. Journal of the American Society of Nephrology 10:314A, 1999

Chen J, Guest S. Inflammatory Demyelinating Neuropathy Presenting in Temporal Relationship with the Initiation of Peritoneal Dialysis. Peritoneal Dialysis 18(5):542, 1998.

Berenji M, Guest S, Erickson L. The Colors of Peritoneal Dialysis. Peritoneal Dialysis Int 17(1):S57, 1997.

Guest S, Berenji M, Erickson L. Management of Pseudomonas Exit Site Infections. Peritoneal Dialysis Int 17(1):S60, 1997.

Erickson L, Cook S, Berenji M, Guest S. Peritoneal Dialysis in an Extended Care Facility - Peritonitis Rate. Peritoneal Dialysis Int 17(1):S73, 1997.

Guest S, Berenji M, Erickson L. Simple, Vancomycin Sparing Regimen for Peritonitis - Update. Peritoneal Dialysis Int 17(1):S32, 1997.

XVIITH Annual CAPD Conference: Berenji M, Erickson L, Guest S: "An Unusual Source of Recurrent Peritonitis?" Poster Presentation, Denver CO. February 17, 1997.

Guest S, Berenji M, Kirsch C, Young J, Kearns P. Functional Consequences of Correction of Metabolic Acidosis in Hemodialysis Patients. J Am Soc Nephrol 8:236A, 1997.

Guest S, Cook S, Berenji M. A Simple Example of Cost Containment. Peritoneal Dial Int 16(2):S25, 1996.

Berenji M, Erickson L, Guest S. Two Vietnamese Patients With Refractory Hypertension: Lessons Learned. Peritoneal Dial Int 16(2):S85, 1996.

Guest S, Erickson L, Berenji M. Simple, Non-Vancomycin Regimen for Peritonitis. Peritoneal Dial Int 16(2):S39, 1996.

Witzgall R, Guest SS, Ouellette AJ, Bonventre JV. Cloning of a Developmentally Regulated, Zinc-Finger Rich, Putative Transcription Factor From the Rat Kidney. JASN 3:22A, 1991.

LECTURES AND PRESENTATIONS: (partial listing)

Active Faculty member of PD University- speak to fellows attending this conference on “infrastructure/Starting a PD Program” “Life Plan for ESRD”. Speak at PDU for Nurses on topic “Catheters and Catheter Dysfunction” Non-infectious Complications of PD”.
Active faculty 2007-2009.

“Medical and Surgical Treatment of Encapsulating Peritoneal Sclerosis in 2008”
“Preserving Peritoneal Membrane Function”
Annual Dialysis Conference- March 2008
Orlando, Florida

Council on Renal Nutrition of N. California/Northern Nevada- January 28, 2008
“Overview of Clinical Data for Peritoneal Dialysis”
San Jose, California

PD University, Phoenix Arizona, December 2-4, 2007. 4 presentations: PD Infrastructure, Journa Club, PD in the Diabetic Pateint, Long Term Care Plan for PD Patients. Wake Forest Feb 2008.

“ Preparing for and Dealing with Life on Dialysis” National Kidney Foundation Symposium San Francisco, September 15, 2007

“PD Solutions” and “Update of Peritoneal Fibrosis and Treatment” Annual Dialysis Conference, Denver, Feb 18, 2007.

“ISPD Meeting in Hong Kong- Update on PD”. Stanford University Division of Nephrology. January 23, 2007.

“Top Renal Articles of the Year” Talk given yearly to Dept of Medicine Faculty- 2003 to present.

Medical Residents Noon Conference- Renal talk given monthly to Internal Medicine housestaff- Kaiser Santa Clara. 2005 to present.

Stanford Medical School- three talks a month to 3rd year students rotating though Kaiser Permanente Internal Medicine wards. 2005-2006.

Kaiser National Internal Medicine and Family Practice Symposium, Oahu Hawaii, July 15-22, 2005. “Management of the Difficult Hypertensive Patient” , “Early Detection of Renal Disease and Strategies to Slow Progression”, “CKD Staging and Action Plan for Each Stage”. Repeated in June 2006 to Kaiser Permanente Family Medicine Symposium and July 2006- by repeat invitation.

Economics of Dialysis- PD versus HD. Enable Healthcare and Baxter. San Francisco, June 11, 2005.

Home First Initiative- Kaiser Permanente Southern California. Invited speaker at day long seminar with Kaiser nephrologists to promote the wider use of Peritoneal Dialysis as the first choice for dialysis. August 2005

Medical Symposium on Kidney Disease, National Kidney Foundation of Northern California: “Kidneys at Risk Versus Failure: Knowing When to Intervene” “Management of CKD”. San Jose, California, February 25, 2004.

Annual Dialysis Conference. “On-line Monitoring of Blood Volume and Cardiovascular Function” and “Improving Outcomes Using Blood Volume Monitoring”. February 9-11, 2004. San Antonio, Texas.

Stanford Division of Nephrology Research Conference: Pure Red Cell Aplasia Secondary to Antierythropoietin Antibodies. September 18, 2003.

SCVMC Medical Grand Rounds: “Antigenic Complications of Recombinant Hormone Therapy” August 29, 2003.

Stanford Division of Nephrology Research Conference: “Growth Hormone Resistance in Uremia, Mechanisms and Clinical Consequences” August 7, 2003.

Kaiser-Santa Clara Medical Grand Rounds: ‘Top Renal Articles of 2003”. July 22 , 2003.

Santa Clara Valley Medical Resident Noon conference- Central Pontine Myelinolysis, December 14, 2002.

Kaiser-Santa Clara Medical Ground Rounds: “Vasopeptidase Inhibitors” August 18, 2002.

Kaiser-Santa Clara Medical Grand Rounds: "Sodium Intake and Hypertension". August 7, 2001

SCVMC Medical Grand Rounds: “Salt Sensitivity”. July 13, 2001.

Stanford University School of Medicine, 2nd Year Class: "Acute Renal Failure". Annual lecture.

Stanford University School of Medicine, 2nd Year Class: "Potassium Balance". Annual lecture.

Stanford University School of Medicine, 2nd Year Class: "Sodium Disorders". Annual lecture.

Stanford Nephrology Research Conference: "Functional Consequences of Chronic Metabolic Acidosis". May 9, 1996.

NKF Renal Care Conference: "Understanding Peritoneal Dialysis". March 2, 1997.

UCSF Stanford Health Care Asia Nephrology Symposium: "Management of Hypertension in End Stage Renal Disease" and "Management of Diabetes Complications in ESRD", Manila, Philippines. April 16, 1998.

UCSF Stanford Health Care Asia Nephrology Symposium: "DOQI Guidelines" and "Diabetic and Hypertensive Management in ESRD Patients", Taipei, Taiwan. April 19, 1998.

Medical Grand Rounds, Kaiser Santa Clara: "Secondary Hypertension". May 12, 1998.

OB-GYN Grand Rounds, SCVMC: “Post-Partum Hemolytic Uremic Syndrome” . February 17, 2000.

Human Physiology, Stanford College: “Clinical Disorders of Osmolality”. Yearly. 1998-2004.

US PATENT APPLICATION:

Guest Acute Peritoneal Dialysis Catheter

The Magnipulator (device for manipulating malpositioned peritoneal dialysis catheters)

INVITED REVIEWER:

American Journal of Kidney Disease

Kidney International

The Annals of Pharmacotherapy

Peritoneal Dialysis International

Infection

Revised 5/10/09